Apple Pharmaceuticals
Apple Pharmaceuticals
Andheri West, Mumbai, Maharashtra
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Hepatitis 1

We are a leading Wholesaler,Exporter,Distributor,Importer,Manufacturer,Trader,Retailer of natdac tablets, velasof tablet, hepcvir l, sofab lp tablets, entehep tablet and sofocure tablets from Mumbai, India.

Natdac Tablets

Natdac Tablets
  • Natdac Tablets
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Approx. Price: Rs 2,500 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
BrandNatdac
Dose/Strength (e.g. 1 mg )60 mg
Packaging Size28 Tablets

Indication:
  • Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.
  • Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
  • These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.
  • Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.
  • Mechanism of action:The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b.
  • Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes.
  • We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking. Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV. These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web.
  • Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation.

Dosage and Administration:

  • Take daclatasvir exactly as your healthcare provider tells you to.·
  • Do not change your dose unless your healthcare provider tells you to.·
  • Do not stop taking daclatasvir without first talking with your healthcare provider.·
  • Take daclatasvir 1 time each day with or without food.The recommended usage of daclatasvir to treat chronic hepatitis C virus is 60 mg taken orally once daily with or without food in combination with sofosbuvir.
  • The recommended treatment duration is 12 weeks.

Side effects:

  • Tiredness, headache, nausea, or diarrhea may occur.
  • If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.
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Velasof Tablet

Velasof Tablet
  • Velasof Tablet
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Approx. Price: Rs 13,990 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
BrandVelasof
Dosage FormTablet
Dose/Strength (e.g. 1 mg )400 mg & 100 mg
Packaging Size28 Tablets

Indication:
  • Velasof is an combination of velpatasvir 100mg+ Sofosbuvir 400mg.
  • Velasof is a two-drug combination for the treatment of hepatitis C.
  • It is administered as a single daily pill containing the viral NS5A inhibitor velpatasvir and sofosbuvir,a nucleotide inhibitor of the viral RNA polymerase.
  • It is the first treatment, that works for all genotypic, and is taken entirely by mouth.
  • A single tablet regimen is used for adults with genotype 1-6 chronic hepatitis C virus (HCV) infection with pangenotypic activity.

Side effects:
  • The most common adverse reactions with velpatasvir were headache and fatigue and when used with RBV in decompensated cirrhotics were fatigue, anemia, nausea, headache, insomnia, and diarrhea.
  • Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.
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Hepcvir L

Hepcvir L
  • Hepcvir L
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Approx. Price: Rs 11,500 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
BrandHepcvir L
Packaging Size28 Tablets
UsageClinical, Hospital

Indication:
  • Treating chronic hepatitis C virus (HCV) infection in certain patients.
  • Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents.
  • It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.


Mechanism of action:

  • Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion.
  • Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication.
  • The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.
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Sofab LP Tablets

Sofab LP Tablets
  • Sofab LP Tablets
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Approx. Price: Rs 15,000 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
Dosage FormTablet
Dose/Strength (e.g. 1 mg )90 mg & 400 mg
Packaging Size28 Tablets

Indication:
  • Treating chronic hepatitis C virus (HCV) infection in certain patients.
  • Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents.
  • It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Mechanism of action:

  • Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion.
  • Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication.
  • The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

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Entehep Tablet

Entehep Tablet
  • Entehep Tablet
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Approx. Price: Rs 1,350 / Piece

Product Details:

Minimum Order Quantity1 Piece
Brand EnteHep
Dose/Strength (e.g. 1 mg )1 mg
Packaging Size1x30

Indication:
  • Entecavir is used to treat long-term hepatitis B infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus.
  • Long-term infection can cause liver damage, rarely liver cancer, and liver failure.
  • Entecavir helps to decrease the amount of hepatitisB virus in your body.
  • It is unknown if this medication lowers your chance of gettingliver cancer or liver damage.
  • Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.

Mechanism of action:

  • Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease.
  • It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV.
  • Entecavir is weakly active against HIV, however it is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV.

Dosage and Administration:

  • Take entecavir on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal.·
  • Entecavir works best if it is taken at the same time each day.· Continue to take entecavir even if you feel well.
  • Do not miss any doses.·
  • If you miss a dose of entecavir, take it as soon as possible.
  • If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
  • Do not take 2 doses at once.
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Sofocure Tablets

Sofocure Tablets
  • Sofocure Tablets
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Approx. Price: Rs 4,800 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
Dosage FormTablet
Dose/Strength (e.g. 1 mg )400 mg
Packaging Size28 Tablets

Indication:
  • It is used for the treatment of hepatitis Cvirus (HCV) infection.
  • It has been marketed since 2013.
  • Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon, an injectable drug with severe side effects.
  • That is a key component of older drug combinations for the treatment of HCV.
  • Sofosbuvir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3, and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone.
  • It is also used in combination with the viral NS5a inhibitor ledipasvir in an interferon-free combination for the treatment of genotype 1 hepatitis C infection.
  • Sofosbuvir is also used in HCV patients with an HIV coinfection.
  • The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.

Mechanism of action:
  • Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase.
  • The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.
  • The drug is available for oral use in the form of 400mg tablets.

Dosage and Administration:

  • The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food.
  • Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults.
  • It is highly advisable to administer the drug under strict medical supervision and advice
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Entecavir Medicines

Entecavir Medicines
  • Entecavir Medicines
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Approx. Price: Rs 2,250 / Pack

Product Details:

Minimum Order Quantity1 Pack
BrandEntecavir
Dose/Strength (e.g. 1 mg )1 mg
Packaging Size1x30

Uses:
  • Entecavir Medicines containing the active ingredient sofosbuvir is a nucleotide polymerase inhibitor type of antiviral medication used to treat Hepatitis C.
  • Entecavir Medicines must be used in combination with other antiviral medicines to reduce the amount of hepatitis C virus (HCV) in the body to help the liver recover.
  • Chronic hepatitis C infections can cause serious liver problems such as liver cancer or cirrhosis (scarring).
  • Patients with HIV or liver cancer and are going to have a liver transplant may also use the drug to decrease the risk of reinfection after the transplant.
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Entehep 0.5mg

Entehep 0.5mg
  • Entehep 0.5mg
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Approx. Price: Rs 740 / Piece

Product Details:

Minimum Order Quantity1 Piece
BrandEnteHep
Dose/Strength (e.g. 1 mg )0.5 mg
Packaging Size1x30

Indication:
  • Entecavir is used to treat long-term hepatitis B infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus.
  • Long-term infection can cause liver damage, rarely liver cancer, and liver failure.
  • Entecavir helps to decrease the amount of hepatitisB virus in your body.
  • It is unknown if this medication lowers your chance of gettingliver cancer or liver damage.
  • Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.

Mechanism of action:
  • Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease.
  • It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV. Entecavir is weakly active against HIV, however it is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV.

Store:
  • Store entecavir in the original carton at room temperature, between 68 and 77 degrees F (20 and 25 degrees C).
  • Store away from heat, moisture, and light.
  • Do not store in the bathroom.
  • Keep entecavir out of the reach of children and away from pets.
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Hepcvir Tablets

Hepcvir Tablets
  • Hepcvir Tablets
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Approx. Price: Rs 9,000 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
BrandHepcvir
Dosage FormTablet
Dose/Strength (e.g. 1 mg )400 mg

Indication:
  • It is used for the treatment of hepatitis Cvirus (HCV) infection.
  • Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon,an injectable drug with severe side effects.
  • That is a key component of older drug combinations for the treatment of HCV.


Mechanism of action:

  • Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase.
  • The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.
  • The drug is available for oral use in the form of 400mg tablets.

 

Dosage and Administration:

  • The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food.
  • Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults.
  • It is highly advisable to administer the drug under strict medical supervision and advice.

 

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Sovihep Tablets

Sovihep Tablets
  • Sovihep Tablets
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Approx. Price: Rs 5,800 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
BrandSoviHep
Dosage FormTablet
Dose/Strength (e.g. 1 mg )400 mg
Packaging Size28 Tablets

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Hepcivir Tablets

Hepcivir Tablets
  • Hepcivir Tablets
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Approx. Price: Rs 5,000 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
BrandCipla
Dosage FormTablet
Dose/Strength (e.g. 1 mg )400 mg

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Daclahep Tablets 60mg

Daclahep Tablets 60mg
  • Daclahep Tablets 60mg
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Approx. Price: Rs 3,500 / Bottle

Product Details:

Minimum Order Quantity3 Bottle
Product TypeFinished Product
Dose60 mg
UsageClinical, Hospital
Packaging Size28 Tablets
Packaging TypeBottle

Indication:
  • Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.
  • Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
  • These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.
  • Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

 

Mechanism of action:

  • The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b.
  • Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes.
  • We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain.
  • Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking.
  • Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV.
  • These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web.
  • Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation. 

 

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Velpanat Tablet

Velpanat Tablet
  • Velpanat Tablet
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Approx. Price: Rs 14,000 / Bottle

Product Details:

Minimum Order Quantity3 Bottle
Packaging Size28 Tablets
Dose/Strength (ex. 1 mg or 1 ml)100 mg/400 mg
UsageClinical, Hospital

Velpanat medication is a combination of sofosbuvir and velpatasvir. This drug work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover Natco Sofosbuvir and Velpatasvir is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It may sometimes be used with another antiviral medication (ribavirin).
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Hepcinat LP

Hepcinat LP
  • Hepcinat LP
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Approx. Price: Rs 12,000 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
Product TypeFinished Product
UsageClinical, Hospital
Packaging Size28 Tablets
Packaging TypeBottle

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Velpanat Tablet

Velpanat Tablet
  • Velpanat Tablet
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Approx. Price: Rs 14,000 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
Packaging Size28 Tablets
Packaging TypeBottle
Dose/Strength (ex. 1 mg or 1 ml)100 mg/400 mg
UsageClinical, Hospital

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Velasof Tabltes

Velasof Tabltes
  • Velasof Tabltes
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Approx. Price: Rs 13,500 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
BrandVelasof
Dose/Strength (ex. 1 mg or 1 ml)100 mg/400 mg
UsageClinical, Hospital

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Velasof Tablet

Velasof Tablet
  • Velasof Tablet
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Approx. Price: Rs 13,500 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
Dosage FormTablet
Dose/Strength (e.g. 1 mg )400 mg & 100 mg
Packaging Size28 Tablets

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Velasof Tabltes

Velasof Tabltes
  • Velasof Tabltes
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Approx. Price: Rs 13,500 / Bottle

Product Details:

Minimum Order Quantity1 Bottle
Dosage FormTablet
Dose/Strength (e.g. 1 mg )400 mg & 100 mg
Packaging Size28 Tablets

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