Apple Pharmaceuticals

Ribahep 200mg ( Ribavirin) is used in combination with other antiviral medications to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. Ribahep 200mg ( Ribavirin) works by reducing the amount of hepatitis C virus in your body, which may help your liver recover.

Mechanism of action:

Ribahep 200mg ( Ribavirin) is readily phosphorylated intracellularly by adenosine kinase to Ribahep 200mg ( Ribavirin) mono-, di-, and triphosphate metabolites. Ribahep 200mg ( Ribavirin) triphosphate (RTP) is a potent competitive inhibitor of inosine monophosphate (IMP) dehydrogenase, viral RNA polymerase and messenger RNA (mRNA) guanylyltransferase (viral) and can be incorporated into RNA in RNA viral species.. Guanylyltranserase inhibition stops the capping of mRNA. These diverse effects result in a marked reduction of intracellular guanosine triphosphate (GTP) pools and inhibition of viral RNA and protein synthesis. Rebetol ( Ribavirin) is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity.

Dosage and Administration:

Use Ribahep 200mg ( Ribavirin) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ribahep 200mg ( Ribavirin) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Ribahep 200mg ( Ribavirin) refilled.

· Take Ribahep 200mg(Ribavirin) by mouth with food.

· Drinking extra fluids while you are taking Ribahep 200mg ( Ribavirin) is recommended. Check with your doctor for instructions.

Ask your health care provider any questions you may have about how to use Ribahep 200mg ( Ribavirin).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; dry mouth; dry skin; hair loss; joint pain; loss of appetite; mild headache, nausea, or vomiting; mild stomach pain; tiredness; trouble sleeping; upset stomach; weakness or fatigue. 

Precaution:

Before taking Ribahep 200mg ( Ribavirin), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Store Ribahep 200mg( Ribavirin) between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ribahep 200mg ( Ribavirin) out of the reach of children and away from pets.

Ribasure 200mg( Ribavirin) is used in combination with other antiviral medications to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. Ribasure 200mg ( Ribavirin) works by reducing the amount of hepatitis C virus in your body, which may help your liver recover.

Mechanism of action:

Ribasure 200mg ( Ribavirin) is readily phosphorylated intracellularly by adenosine kinase to Ribasure 200mg ( Ribavirin) mono-, di-, and triphosphate metabolites. Ribasure ( Ribavirin) triphosphate (RTP) is a potent competitive inhibitor of inosine monophosphate (IMP) dehydrogenase, viral RNA polymerase and messenger RNA (mRNA) guanylyltransferase (viral) and can be incorporated into RNA in RNA viral species.. Guanylyltranserase inhibition stops the capping of mRNA. These diverse effects result in a marked reduction of intracellular guanosine triphosphate (GTP) pools and inhibition of viral RNA and protein synthesis. Ribasure ( Ribavirin) is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity.

Dosage and Administration:

Use Ribasure ( Ribavirin) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Ribasure ( Ribavirin) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Ribasure ( Ribavirin) refilled.

· Take Ribasure (Ribavirin) by mouth with food.

· Drinking extra fluids while you are taking Ribasure ( Ribavirin) is recommended. Check with your doctor for instructions.

Ask your health care provider any questions you may have about how to use Ribasure ( Ribavirin).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; dry mouth; dry skin; hair loss; joint pain; loss of appetite; mild headache, nausea, or vomiting; mild stomach pain; tiredness; trouble sleeping; upset stomach; weakness or fatigue. 

Precaution:

Before taking Ribasure ( Ribavirin), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Store Ribasure 200mg ( Ribavirin) between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ribasure ( Ribavirin) out of the reach of children and away from pets.

Indication:

Ribalieva 200mg( Ribavirin) is used in combination with other antiviral medications to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. Ribalieva 200mg ( Ribavirin) works by reducing the amount of hepatitis C virus in your body, which may help your liver recover.

Mechanism of action:

Ribalieva 200mg ( Ribavirin) is readily phosphorylated intracellularly by adenosine kinase to Ribalieva 200mg ( Ribavirin) mono-, di-, and triphosphate metabolites. Ribalieva 200mg ( Ribavirin) triphosphate (RTP) is a potent competitive inhibitor of inosine monophosphate (IMP) dehydrogenase, viral RNA polymerase and messenger RNA (mRNA) guanylyltransferase (viral) and can be incorporated into RNA in RNA viral species.. Guanylyltranserase inhibition stops the capping of mRNA. These diverse effects result in a marked reduction of intracellular guanosine triphosphate (GTP) pools and inhibition of viral RNA and protein synthesis. Ribalieva 200mg ( Ribavirin) is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity.

Dosage and Administration:

Use Ribalieva 200mg ( Ribavirin) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Ribalieva 200mg ( Ribavirin) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Ribalieva 200mg ( Ribavirin) refilled.

· Take Ribalieva 200mg(Ribavirin) by mouth with food.

· Drinking extra fluids while you are taking Ribalieva 200mg ( Ribavirin) is recommended. Check with your doctor for instructions.

Ask your health care provider any questions you may have about how to use Ribalieva 200mg ( Ribavirin).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; dry mouth; dry skin; hair loss; joint pain; loss of appetite; mild headache, nausea, or vomiting; mild stomach pain; tiredness; trouble sleeping; upset stomach; weakness or fatigue. 

Precaution:

Before taking Ribalieva 200mg ( Ribavirin), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Store Ribalieva 200mg ( Ribavirin) between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ribalieva 200mg ( Ribavirin) out of the reach of children and away from pets.

Famtrex 250mg is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

Penvir  500mg  is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

Microvir 250mg is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

Famcimac 250mg is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

Virovir 500mg  is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

Oseltamivir should not be used in place of getting a yearly flu shot. The Centers for Disease Control (CDC) recommends an annual flu shot to help protect you each year from new strains of influenza virus. You can get a flu shot even while using this medicine.

You should not use oseltamivir if you are allergic to it.

Do not use oseltamivir to prevent influenza in a child younger than 3 months old. Do not use this medicine to treat influenza in a child younger than 2 weeks old unless instructed by your doctor.

Tell your doctor if you have ever had:

• kidney disease (or if you are on dialysis);

• heart disease or chronic lung disease;

• a condition causing swelling or disorder of the brain;

• a weak immune system (caused by disease or by using certain medicine);

• hereditary fructose intolerance; or

• if you have used a nasal flu vaccine (FluMist) within the past 2 weeks.

Take oseltamivir exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Start taking this medicine as soon as possible after flu symptoms appear, such as fever, chills, muscle aches, sore throat, and runny or stuffy nose.

Take the oseltamivir capsule with a full glass of water.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Oseltamivir may be taken with food if it upsets your stomach.

To treat flu symptoms: Take oseltamivir every 12 hours for 5 days.

To prevent flu symptoms: Take oseltamivir every 24 hours for 10 days or as prescribed. Follow your doctor's instructions.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Tell your doctor if your symptoms do not improve, or if they get worse.

Store oseltamivir capsules at room temperature away from moisture and heat.

Store liquid medicine in the refrigerator but do not freeze. Throw away any unused liquid after 17 days.

The liquid may also be stored at cool room temperature for up to 10 day

Oseltamivir should not be used in place of getting a yearly flu shot. The Centers for Disease Control (CDC) recommends an annual flu shot to help protect you each year from new strains of influenza virus. You can get a flu shot even while using this medicine.

You should not use oseltamivir if you are allergic to it.

Do not use oseltamivir to prevent influenza in a child younger than 3 months old. Do not use this medicine to treat influenza in a child younger than 2 weeks old unless instructed by your doctor.

Tell your doctor if you have ever had:

• kidney disease (or if you are on dialysis);

• heart disease or chronic lung disease;

• a condition causing swelling or disorder of the brain;

• a weak immune system (caused by disease or by using certain medicine);

• hereditary fructose intolerance; or

• if you have used a nasal flu vaccine (FluMist) within the past 2 weeks.

Take oseltamivir exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Start taking this medicine as soon as possible after flu symptoms appear, such as fever, chills, muscle aches, sore throat, and runny or stuffy nose.

Take the oseltamivir capsule with a full glass of water.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Oseltamivir may be taken with food if it upsets your stomach.

To treat flu symptoms: Take oseltamivir every 12 hours for 5 days.

To prevent flu symptoms: Take oseltamivir every 24 hours for 10 days or as prescribed. Follow your doctor's instructions.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Tell your doctor if your symptoms do not improve, or if they get worse.

Store oseltamivir capsules at room temperature away from moisture and heat.

Store liquid medicine in the refrigerator but do not freeze. Throw away any unused liquid after 17 days.

The liquid may also be stored at cool room temperature for up to 10 days

Oseltamivir should not be used in place of getting a yearly flu shot. The Centers for Disease Control (CDC) recommends an annual flu shot to help protect you each year from new strains of influenza virus. You can get a flu shot even while using this medicine.

You should not use oseltamivir if you are allergic to it.

Do not use oseltamivir to prevent influenza in a child younger than 3 months old. Do not use this medicine to treat influenza in a child younger than 2 weeks old unless instructed by your doctor.

Tell your doctor if you have ever had:

• kidney disease (or if you are on dialysis);

• heart disease or chronic lung disease;

• a condition causing swelling or disorder of the brain;

• a weak immune system (caused by disease or by using certain medicine);

• hereditary fructose intolerance; or

• if you have used a nasal flu vaccine (FluMist) within the past 2 weeks.

Take oseltamivir exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Start taking this medicine as soon as possible after flu symptoms appear, such as fever, chills, muscle aches, sore throat, and runny or stuffy nose.

Take the oseltamivir capsule with a full glass of water.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Oseltamivir may be taken with food if it upsets your stomach.

To treat flu symptoms: Take oseltamivir every 12 hours for 5 days.

To prevent flu symptoms: Take oseltamivir every 24 hours for 10 days or as prescribed. Follow your doctor's instructions.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Tell your doctor if your symptoms do not improve, or if they get worse.

Store oseltamivir capsules at room temperature away from moisture and heat.

Store liquid medicine in the refrigerator but do not freeze. Throw away any unused liquid after 17 days.

The liquid may also be stored at cool room temperature for up to 10 day

• Cytomegalovirus Infection

Microvir 500mg is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

• Breathing problems or wheezing.
• Racing heart.
• Fever or general ill feeling.
• Swollen lymph nodes.
• Swelling of the face, lips, mouth, tongue, or throat.
• Trouble swallowing or throat tightness

• drowsiness.
• diarrhea.
• gas.
• heartburn.
• change in ability to taste food.
• headache.
• numbness, burning, or tingling of the hands, feet, or area around the mouth.
• muscle or joint pain.

Famcimac 500mg is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

• Chronic hepatitis B virus (HBV) infection

The usual advised dose of Ledifos is one tablet should be administered as once a day. In HIV-1 co infected patients, Ledihep dosage consideration is; Patient without cirrhosis: (adult or pediatric of 12 years of age or older with genotype I, IV, V or VI Chronic HCV) The prescribed dose of Ledihep is one tablet should be taken orally as a single dose for 12 weeks.

Without cirrhosis or compensated cirrhosis: Ledifos should be taken alone as a single dose followed for 12 weeks
Therapy experienced without cirrhosis: Ledifos should be taken as a single agent for once a day for 12 weeks
Therapy experienced with compensated cirrhosis: Ledihep tablet should be used for 24 weeks
In decompensated cirrhosis: Ledihep should be combined with ribavirin to be used, followed for 12 weeks

In liver transplantation patients with compensated cirrhosis or without cirrhosis: Ledifos tablet should be combined with ribavirin for 12 weeks.
Genotype IV, V or VI :
Ledihep tablets should be administered alone for 12 weeks for Without cirrhosis or with compensated cirrhosis patients: On the basis of body weight the dose of ribavirin should be calculated <75kg: 1000mg; >=75kg: 1200mg Ribavirin should be administered with food. Ledihep should be administered with or without food.
SIDE EFFECTS 

Elevation of bilirubin Elevation of lipase Elevation of creatine kinase Severe bradycardia HBV reactivation Chest pain Dizziness Trouble in breathing Fatigue Headache Nausea Diarrhea Insomnia
Ledifos tablet Manufactured  by Natco pharma Ltd

Additional Information:

• Port of Dispatch: Mumbai

Penvir  250mg  is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes.

Resof L tablet should be used for both adults & pediatric patients with the age of 12 years or older or weight of at least 35kg. Used for; Genotype I, 4, 5, or 6 with compensated cirrhosis or without cirrhosis Genotype 1 infection with compensated cirrhosis or without cirrhosis Liver transplantation condition, genotype 1 with decompensated cirrhosis by use of ribavirin Genotype 1 or 4 without cirrhosis or with compensated cirrhosis by use of ribavirin Pediatric patients, HCV infection related to genotype 1, 4, 5, or 6 without cirrhosis or with compensated cirrhosis.

The usual advised dose of Resof L is one tablet should be administered as once a day. In HIV-1 co infected patients, Resof L dosage consideration is; Patient without cirrhosis: (adult or pediatric of 12 years of age or older with genotype I, IV, V or VI Chronic HCV) The prescribed dose of Resof L is one tablet should be taken orally as a single dose for 12 weeks

Without cirrhosis or compensated cirrhosis: Resof L should be taken alone as a single dose followed for 12 weeks
Therapy experienced without cirrhosis: Resof L should be taken as a single agent for once a day for 12 weeks

Therapy experienced with compensated cirrhosis: Resof L tablet should be used for 24 weeks
In decompensated cirrhosis: Resof L should be combined with ribavirin to be used, followed for 12 weeks

In liver transplantation patients with compensated cirrhosis or without cirrhosis: Resof L tablet should be combined with ribavirin for 12 weeks.
Genotype IV, V or VI :
Resof L tablets should be administered alone for 12 weeks for without cirrhosis or with compensated cirrhosis patients: On the basis of body weight the dose of ribavirin should be calculated <75kg: 1000mg; 75kg: 1200mg Ribavirin should be administered with food. Resof L should be administered with or without food.
SIDE EFFECTS 

Elevation of bilirubin Elevation of lipase Elevation of creatine kinase Severe bradycardia HBV reactivation Chest pain Dizziness Trouble in breathing Fatigue Headache Nausea Diarrhea Insomnia

Resof L Manufactured & Marketed by Dr.Reddy's Laboratories Ltd

Additional Information:

• Port of Dispatch: Mumbai