Apple Pharmaceuticals

Temonat (Temozolomide) 

Brand name: Temonat

Active Ingeridents(Generic Name) : Temozolomide 

Company Name: Natco

Package: 5 Capsules

Strength: 100mg 

Indication:

It is used as a treatment of some brain cancers; as a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.

Temonat (Temozolomide) is an antineoplastic agent. It works by stopping cancer cells from growing and reproducing.

Mechanism of action:

The therapeutic benefit of Temonat (Temozolomide) depends on its ability toalkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions ofguanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of Temonat (Temozolomide) , by expressing a protein O⁶-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene.In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by Temonat (Temozolomide) .Conversely, the presence of AGT protein in brain tumors predicts poor response to Temonat (Temozolomide) and these patients receive little benefit from chemotherapy with Temonat (Temozolomide). 

Dosage and Administration:

• This medication is given in a capsule form by mouth.
• Take on an empty stomach (1 hour before or 2 hours after meals or at bedtime) to reduce stomach upset.
• Do not open, crush, or chew capsules; swallow capsules whole with full 8 ounces of water.
• The frequency and the amount of this medication you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dosage and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; back pain; breast pain; constipation; cough; diarrhea; dizziness; drowsiness; dry skin; hair loss; headache; joint pain; loss of appetite; mild stomach pain; mouth or tongue sores; muscle aches; nausea; taste changes; tiredness; trouble sleeping; vomiting; weakness; weight gain.

 Precaution: 

• Before starting Temonat (Temozolomide) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor''s approval while taking Temonat (Temozolomide) .
• Let your health care provider know if you''ve had an allergic reaction to this drug or dacarbazine (DTIC) in the past, you may not be able to take temozolamide.

 Store: Temonat (Temozolomide) is usually handled and stored by a health care provider. If you are using Temonat (Temozolomide) at home, store Temonat (Temozolomide) as directed by your pharmacist or health care provider. Keep Temonat (Temozolomide) out of the reach of children and away from pets.

 Quantity : 1 Bottle

Mabtas  Infusion is used in the treatment of non-Hodgkin lymphoma (NHL), rheumatoid arthritis, blood cancer (chronic lymphocytic leukemia), granulomatosis with polyangiitis and microscopic polyangiitis.

Glenvas- Lenvatinib  is an anti-cancer drug for the treatment of certain kinds of thyroid cancer and for other cancers as well and acts as a multiple kinase inhibitor against the VEGFR1, VEGFR2 and VEGFR3 kinases.

Lenvat - Lenvatinib   is an anti-cancer drug for the treatment of certain kinds of thyroid cancer and for other cancers as well  and acts as a multiple kinase inhibitor against the VEGFR1, VEGFR2 and VEGFR3 kinases.

We are manfacturer,trader & supplier of Tacrograf 0.25mg Capsule.

Tacrograf 0.25mg Capsule is used along with other medicines to prevent your body rejecting a new organ (e.g., liver, kidney or heart) after transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body’s immune system, so it does not attack the new organ.

The amount of Tacrograf 0.25mg Capsule you take and how often you take it depends on the type of transplant you have, your body weight and what other medicines you are taking. Follow your doctor’s instructions carefully. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Take this medicine regularly to get the maximum benefit and keep taking it, even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ.

Tacrograf 0.25mg Capsule has many potential side effects. It can cause or worsen diabetes and kidney and liver problems. These need urgent medical attention. Other common side effects include nausea, stomach pain, diarrhea and difficulty sleeping. If these or other side effects do not go away or get worse, tell your doctor. Because it lowers your immune system, you may also catch more infections than usual.

Before taking this medicine, tell your doctor if you have kidney, liver or heart problems, diabetes or high blood pressure. Also let your doctor know what other medications you are taking, especially for infections, pain, and arthritis. These and others may affect, or be affected by, this medicine. You should limit your exposure to the sun and UV (ultraviolet) light while taking it because immunosuppressants could increase your risk of skin cancer.

Both men and women using this medicine should use effective birth control to prevent pregnancy. This medicine is not normally recommended during pregnancy or while breastfeeding unless it is clearly needed. Before and during treatment you will need frequent medical tests to monitor your progress, and your blood pressure will need to be checked often.

USES OF TACROGRAF CAPSULE

Additional Information:

• Production Capacity: Large
• Delivery Time: Immediate
• Packaging Details: 10 Capsules in a strip

• Prostate cancer

Additional Information:

• Delivery Time: Immediate

• Prostate cancer

Additional Information:

• Delivery Time: Immediate

We are manfacturer, trader & supplier of Axpero 1mg/5mgTablet.
Axpero 1mg/5mg Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Additional Information:

• Packaging Details: 1 x 14 Tablets in a strip

Additional Information:

• Delivery Time: 24 - 48 hours

We are manfacturer, trader & supplier of Sutinat 12.5mg/ 25mg/ 50mg Capsules.

Sutinat 12.5mg/ 25mg/ 50mg Capsules is an antineoplastic medication. Sutinat 12.5mg/ 25mg/ 50mg Capsules is a tyrosine kinase inhibitor. Sutinat 12.5mg/ 25mg/ 50mg Capsules inhibits vascular endothelial growth factor. It is used in the treatment of gastrointestinal stromal tumor, renal cell carcinoma, and pancreatic neuroendocrine tumor. This medication is recommended only for adults.

Uses of Sutinat 12.5mg/25mg/50mg Capsules 

Sutinat 12.5mg/25mg/50mg Capsules is used in treatment of pancreatic cancer, GI tumor and kidney cancer.