Apple Pharmaceuticals

Lenvaheal 4 - Lenvatinib 4mg Capsules

Description:
Lenvaheal 4 contains Lenvatinib 4mg is an oral multi-kinase inhibitor, available in 4mg capsule form, used in the treatment of certain types of cancer, such as thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. It works by inhibiting angiogenesis and tumor cell proliferation.

Uses:
Lenvaheal 4 - Lenvatinib 4mg capsule is indicated for the treatment of:

• Differentiated thyroid cancer (DTC) that is refractory to radioactive iodine treatment
• Advanced renal cell carcinoma (in combination with other agents)
• Unresectable hepatocellular carcinoma

Metabolism:
Lenvatinib is metabolized primarily in the liver, mainly via cytochrome P450 enzymes (CYP3A). It undergoes oxidation and demethylation, with the main circulating metabolite being an inactive form.

Adverse Effects:
Common adverse effects include:

• Hypertension
• Fatigue
• Diarrhea
• Decreased appetite
• Weight loss
• Nausea
• Stomatitis
  Serious side effects may include arterial thromboembolic events, liver impairment, and proteinuria.

Distribution:
Lenvatinib is highly protein-bound (approximately 98-99%) in plasma. The volume of distribution is moderate, indicating some tissue penetration.

Excretion:
Lenvatinib and its metabolites are excreted mainly via feces (about 64%), with a smaller portion excreted in urine (approximately 25%). The elimination half-life is about 28 hours.

Dosage:
The recommended starting dose for adults varies depending on the cancer type and combination with other drugs. For differentiated thyroid cancer, the usual starting dose is 24 mg orally once daily. Dose adjustments may be required based on tolerability and adverse reactions.

Additional Information:

• Delivery Time: 1-2 days
• Packaging Details: 30 capsules in a bottle

Description:
Enzamale 40 contains Enzalutamide 40mg Capsules is an oral nonsteroidal antiandrogen medication primarily used for the treatment of prostate cancer. It acts by inhibiting androgen receptors, thereby blocking the effects of male hormones that can promote tumor growth.

Uses:
Enzamale 40 Enzalutamide 40mg capsules is indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and non-metastatic castration-resistant prostate cancer (nmCRPC).

Metabolism:
Enzalutamide is extensively metabolized in the liver, primarily by the cytochrome P450 enzymes CYP2C8 and CYP3A4 to its active metabolite, N-desmethyl enzalutamide.

Adverse Effects:
Common adverse effects include fatigue, hot flashes, hypertension, headache, and falls. Serious side effects may include seizures, posterior reversible encephalopathy syndrome, and cardiovascular events.

Distribution:
Enzalutamide is highly protein-bound (~97-98%) and has a large volume of distribution, indicating wide tissue penetration.

Excretion:
The drug and its metabolites are primarily excreted in the urine (approximately 71%) and to a lesser extent in feces (approximately 14%). Most of the excreted drug is in the form of metabolites.

Dosage:
The recommended dosage for adults is 160 mg once daily (administered as four 40 mg capsules) with or without food.

Additional Information:

• Delivery Time: 1-2 days
• Packaging Details: 28 Capsules in a bottle

Anastrol 1 - Anastrozole 1mg Tablet

Description:
Anastrol 1 contains Anastrozole 1mg tablet is a non-steroidal aromatase inhibitor used primarily in the treatment of hormone receptor-positive breast cancer. It works by lowering estrogen levels in the body, which helps slow or stop the growth of certain types of breast tumors that require estrogen to grow.

Uses:

• Treatment of postmenopausal women with hormone receptor-positive breast cancer
• Adjuvant therapy for early breast cancer
• Treatment of advanced or metastatic breast cancer

Metabolism:
Anastrozole is extensively metabolized in the liver, primarily by N-dealkylation, hydroxylation, and glucuronidation. The main metabolites are inactive and are excreted in urine.

Adverse Effects:

• Hot flashes
• Joint pain or stiffness (arthralgia)
• Weakness and fatigue
• Osteoporosis and increased fracture risk
• Nausea
• Headache
• Rash
• Elevated cholesterol levels

Distribution:
Anastrozole is moderately bound to plasma proteins (about 40%). It is widely distributed throughout the body, with a volume of distribution of approximately 81 liters in adults.

Excretion:
Anastrozole and its metabolites are primarily excreted via the urine, with about 60% of a dose found in the urine within 72 hours. Only about 10% is excreted unchanged.

Dosage:
The recommended dose for adults is 1 mg orally once daily, with or without food. Dosage adjustments are generally not required for elderly patients or those with mild-to-moderate liver or kidney impairment.

Additional Information:

• Delivery Time: 1-2 days
• Packaging Details: 10 tablets in a strip

Abiramale 250 - Abiraterone Acetate 250mg Tablets

Description:
Abiramale 250 contains Abiraterone acetate 250mg is an orally administered prodrug of abiraterone, a selective inhibitor of the enzyme CYP17A1, which is involved in androgen biosynthesis. It is primarily used in the treatment of metastatic castration-resistant prostate cancer (mCRPC).

Uses:
Abiramale 250 - Abiraterone acetate tablet is indicated for use in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer. It is also sometimes used in metastatic high-risk castration-sensitive prostate cancer.

Metabolism:
After oral administration, abiraterone acetate is rapidly converted in vivo to abiraterone, its active form. Abiraterone is metabolized mainly in the liver via the CYP3A4 pathway and, to a lesser extent, by SULT2A1.

Adverse Effects:
Common adverse effects include hypertension, hypokalemia, fluid retention, liver function abnormalities, joint swelling or discomfort, and hot flushes. Rare but serious effects include hepatotoxicity and cardiac disorders.

Distribution:
Abiraterone is highly protein-bound (>99%) in plasma. It is widely distributed in the body, but does not significantly cross the blood-brain barrier.

Excretion:
Abiraterone and its metabolites are primarily excreted via the feces (about 88%), with a minor proportion excreted in urine (about 5%).

Dosage:
The recommended dose is 1000 mg (four 250 mg tablets) taken once daily on an empty stomach, in combination with prednisone 5 mg administered orally twice daily. Dosage adjustments may be required in cases of hepatic impairment.

Additional Information:

• Delivery Time: 1-2
• Packaging Details: 120 Tablets in a bottle

Olanib 150 - Olaparib 150mg Tablets

Description:
Olanib 150 contains Olaparib 150mg tablet is an oral poly (ADP-ribose) polymerase (PARP) inhibitor used primarily in the treatment of certain types of cancers, including ovarian, breast, pancreatic, and prostate cancers. The 150mg tablet is a film-coated formulation designed for systemic therapy.

Uses:
Olanib 150 – Olaparib 150mg tablet is indicated for the treatment of patients with BRCA-mutated advanced ovarian, breast, pancreatic, or prostate cancer. It is typically used when other treatments have been unsuccessful or as maintenance therapy following initial cancer response to platinum-based chemotherapy.

Metabolism:
Olaparib is metabolized mainly in the liver, primarily by the cytochrome P450 enzyme CYP3A4. The drug undergoes oxidation and subsequent conjugation, producing metabolites that are less active than the parent compound.

Adverse Effects:
Common adverse effects include nausea, fatigue, anemia, vomiting, diarrhea, and decreased appetite. More serious side effects can include myelodysplastic syndrome, acute myeloid leukemia, and pneumonitis. Regular monitoring of blood counts is recommended during therapy.

Distribution:
Olaparib is widely distributed throughout the body after oral administration, with moderate binding to plasma proteins (approximately 82%).

Excretion:
The drug and its metabolites are excreted primarily via urine (approximately 44%) and feces (approximately 42%). The elimination half-life is about 12 hours.

Dosage:
The recommended dose for adults is 300mg (two 150mg tablets) taken orally twice daily. Dosage adjustments may be necessary based on individual tolerability, renal or hepatic impairment, and side effect profile. Treatment should continue until disease progression or unacceptable toxicity occurs.

Additional Information:

• Delivery Time: 1-2 days
• Packaging Details: 30 Tablets in a bottle

Palboheal 125 - Palbociclib 125mg Capsules

Description:
Palboheal 125 contains Palbociclib 125mg capsule is an oral anticancer medication classified as a selective cyclin-dependent kinase (CDK) 4/6 inhibitor. It is used primarily in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced or metastatic breast cancer, often in combination with other hormonal therapies.

Uses:
Palboheal 125 – Palbociclib 125mg capsules is indicated for the treatment of HR+/HER2- advanced or metastatic breast cancer, generally in combination with an aromatase inhibitor or fulvestrant, in postmenopausal women or in men.

Metabolism:
Palbociclib is extensively metabolized in the liver, predominantly by cytochrome P450 3A (CYP3A) and sulfotransferase enzymes (SULT2A1). The major metabolic pathways result in inactive metabolites.

Adverse Effects:

• Neutropenia
• Leukopenia
• Fatigue
• Infections
• Nausea
• Stomatitis
• Anemia
• Thrombocytopenia
  Serious adverse effects may include severe neutropenia, febrile neutropenia, and increased risk of infections.

Distribution:
Palbociclib is moderately bound to plasma proteins (approximately 85%). It has a large volume of distribution, indicating extensive tissue penetration.

Excretion:
Palbociclib is eliminated primarily via feces (about 74%) and to a lesser extent via urine (about 17%). The drug and its metabolites are excreted mainly through hepatic metabolism.

Dosage:
The recommended dose of Palbociclib is 125 mg taken orally once daily for 21 consecutive days followed by 7 days off treatment, in a 28-day cycle. Dose adjustments may be necessary based on tolerability and adverse effects.

Additional Information:

• Production Capacity: 100000
• Delivery Time: 1-2 days
• Packaging Details: 21 capsules in a bottle

Azacitidine 100mg Injection for injection is used for treating adults with Myelodysplastic syndrome (MDS) and Acute myeloid leukemia (AML) if they are considered ineligible for stem cell transplant. In Myelodysplastic Syndrome, the bone marrow does not produce healthy blood cells due to its lack of function. Acute Myeloid Leukemia is a type of bone marrow cancer caused by the release of incompletely formed blood cells into the bloodstream.

• Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
• Intermediate-2 and High-risk Myelodysplastic syndrome (MDS)

In MDS and AML, the development of tumor cells is caused by the process of transcriptional repression of various genes, which is due to the hypermethylation of DNA. Transcriptional repression is a process where proteins bind directly or indirectly to DNA and control the activity of copying a specific gene or a set of genes. The active form of Azacitidine 100mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells, and exhibits a toxic effect on cancer cells.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Azacitidine 100 mg injection and cause undesirable side effects. 

Store at room temperature (15-30°C). If the product is reconstituted, it must be used immediately; if not, store at 2-8°C for not more than 8 hours. Keep the injection out of sight and reach of children.

Take Azacitidine 100mg Injection only under the supervision of your physician. Your physician will decide the dose based on your height, weight, and general condition. It shall be given under the skin of your thigh, stomach, or upper arm.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Unexpected bleeding, with blood in stool and urine
• Fever
• Pneumonia is characterized by chest pain or breathlessness.
• Allergic reaction with symptoms of swelling of lips, itching, or rashes.
• Seizures, loss of consciousness, severe headache, or bleeding in the brain
• Frequent urination with pain or burning sensation

Additional Information:

• Production Capacity: Large
• Delivery Time: Immdiately

• Purpose: To prevent or reduce liver injury that can occur after a potentially harmful overdose of acetaminophen (paracetamol). 

• Mucolytic: Acetylcysteine is also known for its mucolytic properties, meaning it loosens and breaks down thick mucus. 

Additional Information:

• Production Capacity: Large
• Delivery Time: Immediately
• Packaging Details: 5 Ampoules in a box

Gabasmile 100 Tablet belongs to the anti-epileptic group of medicines. You may take it with or without food, but it is important to take this medicine at the same time each day to get the most benefit. The exact dose and duration of treatment will depend on your condition and how you respond to it. Your doctor will probably start this medicine at a low dose and increase it gradually. It may take a few weeks for the medicine to work properly. Follow your doctor’s instructions and continue taking it regularly until your doctor advises you to stop. Do not miss any dose, otherwise, your condition may worsen.

Most people taking Gabasmile  100 Tablet do not experience any side effects. The most common ones are feeling sleepy, dizzy, or tired (fatigue). These are usually mild and go away by themselves as your body gets used to the medicine. Most side effects are not serious and do not need medical attention. Talk to your doctor if any of the side effects persist or worry you.

You should avoid drinking alcohol along with this medicine as it may lead to excessive sleepiness and dizziness. Let your doctor know right away if you develop any unusual mood changes like anxiety, agitation, depression, or thoughts about harming yourself.

Before taking Gabasmile  100 Tablet, you should tell your doctor if you have any kidney-related problems or if you are more than 65 years old. Your doctor may prescribe a different dose in such people. Women who are pregnant, breastfeeding, or planning to become pregnant should also consult their doctor before using this medicine.

Additional Information:

• Production Capacity: 100000
• Delivery Time: 24- 48 hours
• Packaging Details: 10 x 10s Blister pack